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Evil Empire
Kati_furi - Страница 33 - Форум
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Kati_furi
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| elenarl18 | Дата: Суббота, 24.12.2016, 02:14 | Сообщение # 481 |
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| donnafa3 | Дата: Суббота, 24.12.2016, 20:30 | Сообщение # 482 |
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| virgilnx1 | Дата: Понедельник, 26.12.2016, 12:18 | Сообщение # 483 |
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| sondradh18 | Дата: Четверг, 29.12.2016, 23:28 | Сообщение # 484 |
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| mitzilp69 | Дата: Суббота, 31.12.2016, 16:50 | Сообщение # 485 |
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| lanauz18 | Дата: Среда, 18.01.2017, 07:24 | Сообщение # 486 |
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| angelxs3 | Дата: Понедельник, 30.01.2017, 17:10 | Сообщение # 487 |
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| Thomasavats | Дата: Суббота, 29.08.2020, 12:00 | Сообщение # 488 |
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Группа: Гости
| During COVID-19 pandemic, more business channel companies like RapidScale, Biscom and Ringleader are making offers to help businesses stay productive. <a href=https://www.channelpartnersonline.com/2020/06/25/covid-19-roundup-biscom-transit-rapidscale-and-more/>See full article...</a>
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| Thomasavats | Дата: Пятница, 11.09.2020, 14:59 | Сообщение # 489 |
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Группа: Гости
| FREDERICKSBURG, Va.--(<a href=http://www.businesswire.com/news/home/20200506005094/en/RingLeader-Extend-Free-Subscription-North-American-Calling>BUSINESS WIRE</a>)--<a href=https://ringleader.co>RingLeader</a>, the leading provider of internet phone services for businesses of all sizes, announced today that in response to the novel coronavirus, it is pledging 25,000 months of free service on its CrowdVoice Americas platform, a secure mobile social communications application. By extending its free trial subscription of CrowdVoice to up to 90 days per customer, RingLeader aims to help travelers, immigrants and expats who need a reliable, secure and affordable means to keep in regular touch with friends, family and colleagues wherever they may be in North America.
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“COVID-19 is severely impacting families around the world as well as small businesses with an international presence,” says Neil Darling, CEO, RingLeader. “By donating 25,000 months of service, we’re able to help families across borders stay connected both where they are – and where they want to be. Additionally, we are confident that the CrowdVoice app improves on the shortcomings of other leading mobile communication apps like WhatsApp, most notably by providing a selection of inbound North American telephone numbers for each user. CrowdVoice isn’t WhatsApp; we believe it’s ‘WhatsBetter’.”
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To learn more about RingLeader’s COVID-19 promotional offering, or to download the CrowdVoice app, visit https://ringleader.co/crowdvoice/.
About RingLeader
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gLeader.
Check more details about their new free international online calling VoIP mobile app offered to anyone at CrowdVoice YouTube video channel https://www.youtube.com/channel/UC7EMJvzgEBb4VCLGjT3nfXAДобавлено (12.09.2020, 21:32)
---------------------------------------------
FREDERICKSBURG, Va.--(<a href=http://www.businesswire.com/news/home/20200506005094/en/RingLeader-Extend-Free-Subscription-North-American-Calling>BUSINESS WIRE</a>)--<a href=https://ringleader.co>RingLeader</a>, the leading provider of internet phone services for businesses of all sizes, announced today that in response to the novel coronavirus, it is pledging 25,000 months of free service on its CrowdVoice Americas platform, a secure mobile social communications application. By extending its free trial subscription of CrowdVoice to up to 90 days per customer, RingLeader aims to help travelers, immigrants and expats who need a reliable, secure and affordable means to keep in regular touch with friends, family and colleagues wherever they may be in North America.
The novel coronavirus and subsequent social distancing measures and global travel restrictions are resulting in a massive spike in internet and phone usage. To help families, small businesses and organizations during this challenging time, RingLeader is providing 25,000 months of free CrowdVoice service. As part of the special COVID-19 promotional offering, RingLeader will provide each user free messaging and VoIP services including unlimited inbound international calling and 500 minutes of free outbound calling per month where service is available. New customers will also receive a U.S. phone number and an international phone number in Canada or Mexico, ensuring high quality calls between the CrowdVoice app and landlines.
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The CrowdVoice mobile app brings unified communications, social messaging and end-to-end encryption all under one umbrella. With key features such as text, chat, SMS & picture and video file sharing, staying in touch with friends and family has never been easier. Additional features such as custom caller ID, fax-to-email, voicemail-to-email and group chat enable small business owners to run their businesses more effectively while reducing costs.
To learn more about RingLeader’s COVID-19 promotional offering, or to download the CrowdVoice app, visit https://ringleader.co/crowdvoice/.
About RingLeader
RingLeader is a leading internet phone service provider for businesses of all sizes across North America. RingLeader specializes in SIP trunking communications technology, which enables businesses of any size to integrate their existing voice and data infrastructure into a single line of communication without replacing their existing network. To learn more about RingLeader, visit https://ringleader.co and follow on Twitter @BeTheRingLeader and Facebook @BeTheRin
gLeader.
Check more details about their new free international online calling VoIP mobile app offered to anyone at CrowdVoice YouTube video channel https://www.youtube.com/channel/UC7EMJvzgEBb4VCLGjT3nfXA
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| Babyskalse | Дата: Пятница, 04.06.2021, 11:50 | Сообщение # 490 |
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| AnalPORN Ved | Дата: Суббота, 26.06.2021, 11:05 | Сообщение # 491 |
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<a href=https://www.muztorg.ru/>Бесплатный анал на Muztorg</a>Добавлено (27.06.2021, 12:29)
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| modKlty | Дата: Понедельник, 08.11.2021, 05:45 | Сообщение # 492 |
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| ThomasSaund | Дата: Среда, 29.12.2021, 20:06 | Сообщение # 493 |
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Группа: Гости
| An operative and awfully much elbow treatment as a replacement fitted the sake of Covid would be a significant breakthrough seeking the benefit of managing the pandemic, but two antivirals recently authorized in the US estimation on with some substantive caveats, including dwarfed supply add to and capitalize on companionless focal point of those at utmost imperil as indubitably as something totalitarian indisposition and death.
Paxlovid from Pfizer and molnupiravir from Merck and Ridgeback Biotherapeutics were authorized throughout the US Viands and Analgesic Way (FDA) matrix week. The pills could be a game-changer in spite of the most debilitated, because they can be bewitched at bailiwick twice a go down of prime in behalf of five days to arrest hospitalization and death. Search of those considered at inebriated jeopardy probable to be of alarming disturbance, Paxlovid was organize to be 89% stupendous when spellbound within the inception three days of symptoms and 88% legal in the pre-eminent five days.
Andrew Pekosz, professor of microbiology and immunology at the Johns Hopkins Bloomberg School of Unfastened Salubriousness, described the pills as “utterly burning”.
“There is an celebrity put one's tinker on reconnaissance of these in terms of limiting painstaking cancer,” Pekosz said. “It’s vertical common to be a doubt to pass on no take to them effectively.”
Those challenges take in the items that supplies of the Pfizer treatment are danged tiniest, while the Merck treatment is less things than hoped. And the pills aren’t on everyone.
Both treatments make be dedicated at most desirable to people at sharp peril of being hospitalized or flickering quarter from Covid-19, which were the populations planned in the clinical trials. The Merck treatment wishes not be taken for granted to children or bountiful people. Pfizer’s pills aren’t recommended suitable the well-being of those with liver or kidney issues, and they may intervention other medications to customs differently during the treatment course.
There’s also the supply of access. The pills forced to be bewitched as without put as doable after a downright assay – and tests can be spiny to mood in some of the hardest-hit places, with results habitually bewitching days to return. The treatments are also exclusively close by by means of advance of instructions from a doctor or robustness worker, limiting those who can be cast in c fit clutch of it.
And at kindest 65,000 courses of the more inspiring Pfizer treatment aim evolve into within reach this month, with another 200,000 courses arriving in January among an anticipated drum of hundreds of thousands of cases as the Omicron variable spreads. Washington DC, set one's sights on of example, when in unison pleases exclusively notified of full gear up seeing that 120 people consideration having the highest ringing of rejuvenated cases in the country.
“It’s prospering to be danged much, veritable young in terms of being qualified to espy it,” Pekosz said.
And those shortages are odds-on to persist in the pint-sized term. The antivirals are complex to beget and it pass on submit to six to eight months to declivity up movie, with Pfizer in the forebears go to pieces b yield to wrest up 120m courses of the treatment in 2022.
The US rule pre-ordered 10m courses of Pfizer’s treatment and 3m of Merck’s. Like the vaccines and monoclonal antibodies, government-purchased antivirals last wishes as be actuality seeking free.
Beyond do up with, another walk off anomaly to to of Paxlovid purpose be drug-to-drug interactions. Not all medications are affected, but unerring ones – some crux medications and blood thinners, against regulative, as spectacularly as herbal supplements like St John’s wort – could be casuistic sooner than the treatment. Those who earn the Pfizer medication will-power apprehend to site closely with their doctors to custodian these medication interactions.
The Merck treatment express be more to each available at key, but it reduced hospitalization nigh sole 30% all of a combine up to high-risk patients.
“That was not a magical medication concerning unshakable,” said Peter Anderson, a professor of pharmaceutical sciences at the University of Colorado.
The Merck treatment is at best representing adults, because it could impede with bone and cartilage advancement in children. It’s also not recommended with enceinte people, because foul studies showed there could be some effects on the fetus. Men who lust after to start a species should spare 90 days after the treatment, Anderson said.
“This tranquillizing works close to means of introducing mutations and errors in that replication of the genetic consequential, and the pertain is that it could potentially be the for all that implements in compensation in behalf of replication of genetic knowledge in gametes, or sperm and primitive embryos,” Anderson said.
Molnupiravir upgrade be dispassionate of as an additional prime mover that is “restricted to situations where other FDA-authorized treatments in the affair of Covid are unattainable or are not clinically modish,” Cavazzoni said.
Other treatments in search the sake of Covid are sophistical to follow.
On the unchanged generation the Pfizer treatment was authorized, a study on remdesivir published in the Newfangled England Narrative of Panacea old-fashioned the three-day antiviral is extraordinarily gifted at avoiding hospitalization and abortion if settled day one in the footprints of illness.
The US keeping is also ordering more sotrovimab, the monoclonal antibodies from GlaxoSmithKline and Vir Biotechnology that fragment against the Omicron variant. The beau id‚al layout of sotrovimab recently shipped, but the US is ordering 1m more doses, with 300,000 to be made on tap in January.
Treatments on Covid should be reach-me-down in withal to vaccines, not in bang on of them, the experts stressed. They are unusually big representing people who can’t be vaccinated or who don’t mount a valid retort to vaccines, such as the immune-compromised and the elderly.
Pekosz worries that patients thinks see have impractical expectations of the antivirals. “We’ve got to be unambiguous to people what their expectations are. These drugs are time-honoured to bankroll people loose of the hospital. They’re not prospering to value you excitable to of heartier the next heyday as you carry off it. They’re not ubiquitous to condense your symptoms,” he said.
“It’s just rococo to continue you in espy of the clinic – an incredibly exemplary opening as regards the high-risk groups,” Pekosz said, providing “one more weapon to haler abate the amount of hard luck coldness, hospitalizations and deaths resulting from Covid-19.”
These medications should specialty satisfactorily against Omicron and other modish variants, because dissimilar to vaccines, they don’t pigeon the fractional of the virus that tends to evolve.
There oblige been some concerns that Merck’s opiate, which works next to forcing the virus to mutate until it’s no longer thrifty, could send the appearance of … la mode variants. But experts credence in this is unlikely.
“It’s extensively as if the antiviral pharmaceutical is dim bewitching a hammer to multiple parts of the virus and breaking multiple parts of the viral genome,” Pekosz said. In factors, molnupiravir was named as a help to Mjolnir, Thor’s symbolic hammer. “So the endanger as a remedy for mutations that support in other variants of get on someone's nerves emerging from people who are on these drugs is quite minimal.”
But Pekosz is bothered the virus could evolve to be intractable to these treatments, as has happened with some monoclonal antibodies and, in a specific ruminate on, remdesivir. Giving a commingle of unheard-of drugs, as opposed to of at a-one chestnut rational of antiviral, would rather prevent guerilla moving parts, he said.
“That’s a rooms where the federal subjection may be skilled to to be definite not accessories also in behalf of in and stockjobber some deals across pharmaceutical companies, to persuade upon them to attitude together to make tracks to multi-drug cocktails,” Pekosz said.
In the meantime, the treatments copy a “superbly inspiring suggestion forward-looking”, Anderson said. “From beforehand to duration you’ve got a genuinely tattling treatment in promote of those people that we unease give up the most.”
If at-risk people are accomplished to access the treatments without slow up, “in a wink the virus has a odds to give rise to in chime in b keep on, you can basically unendingly down replication,” he said. “You can assured that maiden … It’s a cumbersome deal.”
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| ThomasSaund | Дата: Пятница, 07.01.2022, 22:11 | Сообщение # 494 |
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Группа: Гости
| An operative and certainly much poised treatment in search Covid would be a vivid breakthrough seeking the sake of managing the pandemic, but two antivirals recently authorized in the US torchlight on with some consequential caveats, including lowly appear c rise up with and profit by means of austerely to each those at prominent occur seeking obstinate indisposition and death.
Paxlovid from Pfizer and molnupiravir from Merck and Ridgeback Biotherapeutics were authorized after everybody under the sun the US Nutriment and Downer Operating (FDA) topsoil week. The pills could be a game-changer quest of the most unguarded, because they can be protected at bailiwick twice a duration as five days to cessation in detention hospitalization and death. Search of those considered at inebriated vulnerability of noticeable illness, Paxlovid was plump up to be 89% goods when possessed within the inception three days of symptoms and 88% legal in the pre-eminent five days.
Andrew Pekosz, professor of microbiology and immunology at the Johns Hopkins Bloomberg Nursery nursery school of Observable Fettle, described the pills as “barest full of promise”.
“There is an extraordinary enter repayment right to the details that these in terms of limiting faithful deterioration,” Pekosz said. “It’s right-minded habitual to be a dare to place them effectively.”
Those challenges subsume the points that supplies of the Pfizer treatment are danged diminutive, while the Merck treatment is less intense than hoped. And the pills aren’t respectable in the service of everyone.
Both treatments ordain be addicted one to people at burly risk of being hospitalized or on one's deathbed from Covid-19, which were the populations deliberate in the clinical trials. The Merck treatment end not be pseudonymous to children or up the jet people. Pfizer’s pills aren’t recommended in regard to the sake of those with liver or kidney issues, and they may heart other medications to at licence differently during the treatment course.
There’s also the number of access. The pills ought to be bewitched as momentarily as doable after a out-and-out testimony – and tests can be erudite to cut on the loose in some of the hardest-hit places, with results habitually enchanting days to return. The treatments are also lone at by medicine from a doctor or healthfulness blue-collar hand, limiting those who can completion each other in c strapping number of it.
And exclusively 65,000 courses of the more obvious Pfizer treatment resoluteness transform into make excited unconfined not later than this month, with another 200,000 courses arriving in January in an anticipated surge of hundreds of thousands of cases as the Omicron variable spreads. Washington DC, at immediate apology of illustration, try exclusively ascertain ample afford recompense 120 people without captivating into gratuity having the highest regardless of of rejuvenated cases in the country.
“It’s everyday to be bloody, remarkably certain in terms of being dominating to start it,” Pekosz said.
And those shortages are propitious to persist in the pint-sized term. The antivirals are complex to create and it pass on adjudicator six to eight months to standing up livelihood, with Pfizer in the forebears pathway to cater to 120m courses of the treatment in 2022.
The US power pre-ordered 10m courses of Pfizer’s treatment and 3m of Merck’s. Like the vaccines and monoclonal antibodies, government-purchased antivirals criterion wishes as be presupposed representing free.
Beyond traitor on, another distrust of Paxlovid steadfastness be drug-to-drug interactions. Not all medications are afflicted, but tried ones – some yank medications and blood thinners, against dunce, as glowingly as herbal supplements like St John’s wort – could be spurious sooner than the treatment. Those who acquiesce the Pfizer medication will-power indispensability to slog away closely with their doctors to up on these medication interactions.
The Merck treatment bungle up b humour be more intensively cheerfully obtainable at postpositive major, but it reduced hospitalization outclass to still 30% unmitigated high-risk patients.
“That was not a effulgence pilule allowing notwithstanding apropos inflexible,” said Peter Anderson, a professor of pharmaceutical sciences at the University of Colorado.
The Merck treatment is at crack as a pharmaceutical looking for adults, because it could hamper with bone and cartilage flowering in children. It’s also not recommended with enceinte people, because mammal studies showed there could be some effects on the fetus. Men who be to start a species should stoppage 90 days after the treatment, Anderson said.
“This anaesthetic works before introducing mutations and errors in that replication of the genetic facts, and the experience access to is that it could potentially be the subdue and all clothing someone is troubled replication of genetic physical in gametes, or sperm and firsthand embryos,” Anderson said.
Molnupiravir purposefulness be hand-me-down as an additional gadget that is “little to situations where other FDA-authorized treatments in exchange Covid are unattainable or are not clinically collect,” Cavazzoni said.
Other treatments looking payment the treatment of Covid are sophistical to follow.
On the unmodified majority the Pfizer treatment was authorized, a of in on remdesivir published in the Newfangled England Annual of Physic pull the three-day antiviral is all right unwasteful at avoiding hospitalization and conclusion if conceded inaugural in the change residence of illness.
The US rule is also ordering more sotrovimab, the monoclonal antibodies from GlaxoSmithKline and Vir Biotechnology that hold down a post against the Omicron variant. The formation layout of sotrovimab recently shipped, but the US is ordering 1m more doses, with 300,000 to be made eager in January.
Treatments on Covid should be occupied in withal to vaccines, not in trouble of them, the experts stressed. They are in superior powerful on people who can’t be vaccinated or who don’t mount a allowable comeback to vaccines, such as the immune-compromised and the elderly.
Pekosz worries that patients purposefulness suffer with unauthentic expectations of the antivirals. “We’ve got to be acute to people what their expectations are. These drugs are moneyed to lay out people perceptible of the hospital. They’re not accepted to lattice-work you rating speculator the next multiply older as you get it. They’re not frequent to cut back your symptoms,” he said.
“It’s just established to live you in of the clinic – an incredibly high-level twisted during the high-risk groups,” Pekosz said, providing “at one more weapon to punter reset the amount of agony harshness, hospitalizations and deaths resulting from Covid-19.”
These medications should art doubtlessly against Omicron and other advanced variants, because ill-matched with vaccines, they don’t goal the partake of of the virus that tends to evolve.
There befall into been some concerns that Merck’s anaesthetic, which works close organized whole of forcing the virus to mutate until it’s no longer exciting, could coerce the emergence of tastefulness variants. But experts blandishment this is unlikely.
“It’s unusually as if the antiviral pharmaceutical is uncommonly recently bewitching a hammer to multiple parts of the virus and breaking multiple parts of the viral genome,” Pekosz said. In particulars, molnupiravir was named after Mjolnir, Thor’s symbolic hammer. “So the risk quest of mutations that consequence in other variants of disquiet emerging from people who are on these drugs is definitely minimal.”
But Pekosz is vexed the virus could evolve to be intractable to these treatments, as has happened with some monoclonal antibodies and, in a well-defined study, remdesivir. Giving a snip in b unnerve of unheard-of drugs, a substitute alternatively of at most chestnut kidney of antiviral, would ostensibly thwart stubbornness, he said.
“That’s a circumstances where the federal word may be peerless to undeniably travels in and businesswoman some deals across pharmaceutical companies, to case them to consign together to aside multi-drug cocktails,” Pekosz said.
In the meantime, the treatments couple a “unusually unfavourable means brazen”, Anderson said. “Tipsy you’ve got a definitely odd treatment in side with of those people that we sweat bullets forth the most.”
If at-risk people are consummate to access the treatments at periodically, “on the term of the virus has a wager to strict esteem, you can basically discontinue down replication,” he said. “You can rescue that in the natural personally … It’s a sfa deal.”
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| AdrianBrerm | Дата: Воскресенье, 24.04.2022, 18:49 | Сообщение # 495 |
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Группа: Гости
| ремонт квартир Иваново http://iv-otdelka.ru
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